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How about being a compassionate human being who tries to understand the conversation partner’s fears without bowing down to misinformation? If that’s not enough for them because they see debunking their bunk as personal attack, I don’t think anyone from outside of their cult is an acceptable conversation partner for them.
Yeah, everyone is the hero in their own story, so from their perspective, they surely feel like they know things until they meet an actual biologist challenging them.
TERFs invoke half-remembered high-school level biology as if it was mathematical fact. In actual biological reality, nothing is binary or absolute. I don’t need a PhD in computational biology to know that, but if surely helps.